Nearly in 15% of all cases even after all the medical examinations (including laparoscopic intervention) are done, the reasons of male or female infertility still remain unknown. Such cases of unexplained infertility are the most difficult ones, as the doctors can not define what exactly to treat.
There are several factors that can be considered as the signs of unexplained infertility. Among them it’s worth pointing out the ovarian and hormonal factors (irregular development of follicles; absence of ovulation; disorders of the egg structure; genetic egg disorders; production of antibodies destroying the eggs).
Also, infertility might be caused by immune system disorders and obstructions in the fallopian tubes. Changes in the endometrium structure affect the process of implantation and can also be a significant factor of female infertility.
Unexplained fertility might also be caused by the male factor – structural disorders of the sperm cells (changes in their genetic material) or by embryo factors – formation of bad quality embryos or embryos with genetic and chromosomal disorders.
Fortunately, some of these reasons of unexplained infertility might be diagnosed with the use of modern methods of ART. But still, most of these factors remain indefinable.
If case a couple is diagnosed with unexplained infertility, they are offered with several effective kinds of treatment to overcome this type of infertility. The options depend on the patient’s age, duration of infertility, previous pregnancies or abortions/miscarriages and, of course, the couple’s desire to become parents.
It’s worth mentioning the two of the ways of infertility treatment: the ovarian stimulation with IUI (Intrauterine Insemination) and the IVF (In-vitro Fertilization). To avoid polycarpous pregnancy, it’s better not to use IUI if after the stimulation more than 3 follicles bigger than 18mm were formed.