IUI Treatment: Indications and Contradictions

To conceive, a sperm cell have “to make a long trip” from the vagina through  the cervical canal and uterus to the uterine tubes. The only chance for sperm cell to perform his mission successfully is to get in the tube during the ovulation and meet the egg there. Usually, mucus of the cervical canal doesn’t let all the sperm cells pass into the uterus. Only few of the quickest can do this. Intrauterine  Insemination (IUI) is a special medical procedure which give an opportunity to avoid this barrier. In such a case, more sperm cells will meet the egg and due to this the possibility of conceive will increase.

What is  Intrauterine  Insemination (IUI)?

Intrauterine  Insemination (IUI) is one of the oldest and effective methods of infertility treatment according to which a man’s/donor’s specially refined sperm cell  is introduced to the uterus with a catheter. The usage of a catheter seems to be the only one unnatural moment of the whole procedure. That’s why, despite the fact that Intrauterine  Insemination (IUI) is viewed like a method of ART, it’s at most similarto the natural process of  fertilization.

What is sperm “cleaning”?

This is a special procedure conducted in the laboratory. It gives an opportunity to separate sperm cells from the sperm fluid, dead sperm cells, leucocytes, bacteriums and viruses and, at the same time, to select the sperm cells with the best morphology and mobility. Nowadays, Intrauterine  Insemination is never conducted using non-refined sperm cells as it can cause different complications.

What are the indications for Intrauterine  Insemination (IUI) usage?

There are several indications for both spouses which allow them to use Intrauterine  Insemination (IUI) with man’s or donor’s sperm cells.

Intrauterine Insemination (IUI) using man’s sperm

For woman:

vv_ico infertility of unclarified reasons;

vv_ico cervical factor of infertility;

vv_ico presence of antispermic antibodies;

vv_ico ovulatory dysfunction which can be treated;

vv_ico sperm allergy;

vv_ico vaginism.

For man:

vv_ico subfertile sperm;

vv_ico ejaculatory-sexual disorders;

vv_ico retrograde ejaculation (if the amount of sperm cells is enough for Intrauterine  Insemination (IUI);

vv_ico hypospadias;

vv_ico oligospermia (small volume of ejaculation);

vv_ico high viscosity of spermatic plasma;

vv_ico antispermic antibodies;

vv_ico usage of cryo-preservated sperm (also in the cases of the postponed reproduction)

Intrauterine Insemination (IUI) using donor’s sperm

For man:

vv_ico vivid azoospermia;

vv_ico ejaculatory-sexual disorders;

vv_ico unfavorable medical-genetic prognosis

For woman:

vv_ico medical-social indications (on the woman’s wish)

Contra-indications to Intrauterine Insemination (IUI) usage:

vv_ico over 40;

vv_ico somatic and psychological diseases which are incompatible with pregnancy;

vv_ico disorders and pathologies of the uterus because of which it’s impossible to bear a child;

vv_ico tumors of the ovary;

vv_ico malignant neoplasms of any localization;

vv_ico pathology of uterine tubes;

vv_ico infections of genital tract;

vv_ico several unsuccessful IUI attempts;

vv_ico unclarified bleeding in the genital tracts;

vv_ico acute inflammatory disease;

vv_ico syndrome of ovary  hyperstimulation.

Possible Complications by using Intrauterine  Insemination (IUI)

Usually, Intrauterine  Insemination (IUI) doesn’t have harmful influence on your health. But, in some cases, some complications can occur. Please, look through them attentively.

vv_ico allergic reactions connected with the introduction of the medicines for ovulation stimulation;

vv_ico shock reaction for the sperm introduction into the uterus;

vv_ico uterus tonus increase;

vv_ico syndrome of ovary  hyperstimulation ;

vv_ico acute inflammation of female’s genital organs;

vv_ico polycarpous pregnancy and ectopic pregnancy.

To use Intrauterine  Insemination (IUI), both spouses should pass the following examinations and tests:

For woman:

vv_ico general and special gynecological  checkup;

vv_ico examination of the cervical canal flora; vagina purity degree;

vv_ico smear examination;

vv_ico ultrasonic examination of small pelvis organs;

vv_ico physician’s opinion on the patient’s health and possibility to bear a child;

vv_ico determination of blood-group and Rh-factor;

vv_ico clinical blood examination;

vv_ico syphilis, HIV, Hepatitis B and C examinations  (made no more than 3 months before that);

vv_ico IgM, IgG blood count for toxoplasmosis, chlamydia, CMV and rubella

For man:

vv_ico syphilis, HIV, Hepatitis B and C examinations  (made no more than 3 months before that);

vv_ico spermogram;

vv_ico determination of blood-group and Rh-factor;

vv_ico examination for infections.

What fertility drugs are used for Intrauterine  Insemination (IUI)?

Intrauterine Insemination can be conducted without usage of any fertility drugs which stimulate the ovulation. But, it should be remarked that in such cases the possibility of pregnancy is not really high. The numerous medical researches approve that combination of Intrauterine Insemination procedure and proper medicines which stimulate the development of hoses increase the spouses’ chances. Usually the following medicines are used: clomid, letrozole, menopur, gonal, etc. Chronionic gonadotropin which help mature eggs to leave the hose is also used.

Taking into account all the aspects connected with Intrauterine  Insemination (IUI), it’s quite clear that it’s really effective and not too much hazardous method of treatment which gives people an opportunity to fulfil such a strong desire to have children. But, on the other hand, nobody can guarantee you a successful result with 100% of assurance as it depends on several factors like the age of a woman, the duration of infertility, quality of sperm, results of all the examinations and amount of previous IUI attempts.